منابع مشابه
Jnk
What does it do? JNK is important for sending signals from the cell membrane to nuclear transcription factors, increasing their ability to activate transcription. JNK signalling has been implicated in cell growth, oncogenic transformation, cell differentiation and cell death. Stimuli that activate JNK include growth factors, cytokines and just about any kind of stress (see Figure). JNK can be t...
متن کاملRecruitment of JNK to JIP1 and JNK-dependent JIP1 phosphorylation regulates JNK module dynamics and activation.
JIP1 is a scaffold protein that assembles and facilitates the activation of the mixed lineage kinase-dependent JNK module. Results of earlier work led us to propose a model for JIP1-JNK complex regulation that predicts that under basal conditions, JIP1 maintains DLK in a monomeric, unphosphorylated, and catalytically inactive state. Upon appropriate module stimulation, JNK-JIP1 binding affinity...
متن کاملBistability in the JNK cascade
BACKGROUND Important signaling properties, like adaptation, oscillations, and bistability, can emerge at the level of relatively simple systems of signaling proteins. Here, we have examined the quantitative properties of one well-studied signaling system, the JNK cascade. We experimentally assessed the response of JNK to a physiological stimulus (progesterone) and a pathological stress (hyperos...
متن کاملIdentification of new JNK substrate using ATP pocket mutant JNK and a corresponding ATP analogue.
Modification of the ATP pocket on protein kinases allows selective use of an ATP analogue that exhibits high affinity for the altered kinases. Using this approach, we altered the ATP-binding site on JNK and identified N(6)-(2-phenythyl)-ATP, a modified form of ATP that exhibits high specificity and affinity for the modified, but not the wild type form, of JNK. Using modified JNK and its ATP ana...
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ژورنال
عنوان ژورنال: Current Biology
سال: 2000
ISSN: 0960-9822
DOI: 10.1016/s0960-9822(00)00429-2